Mouse Monoclonal Antibody to PTPRM

Supplier: ProMab Technologies
Type of Product: Monoclonal
Description: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP has been shown to mediate cell-cell aggregation through the interaction with another molecule of this PTP on an adjacent cell. This PTP can interact with scaffolding protein RACK1/GNB2L1, which may be necessary for the downstream signaling in response to cell-cell adhesion. Alternative splicing results in multiple transcripts encoding distinct isoforms.
Application: ELISA: 1/10000; WB: 1/500 - 1/2000; ICC: N/A; FCM: N/A; IHC: N/A
Size: 100 ul, 1mg/ml
Species Reactivity: Human
Clone: 1H6D10
Isotype: Mouse IgG1
Immunogen: Purified recombinant fragment of human PTPRM (AA: extra 565-742) expressed in E. Coli.
Formulation: Purified antibody in PBS with 0.05% sodium azide
MW: 163.7kDa
Storage: 4C; -20C for long term storage
Supplier link: http://www.promab.com/index.php?main_page=product_info&products_id=4622
Reference: 1.PLoS One. 2012;7(11):e50183. 2.Exp Lung Res. 2011 Aug;37(6):327-43.

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