Product Type: Antibody
Descritpion: May regulate the expression of IL-2, IL-6, and other cytokines through regulation on NF-kappa-B activity. Functions in the regulation of inflammatory responses. May also regulate TCR-induced negative selection of thymocytes.I?BNS, the nuclear I?B-like protein encoded by Nfkbid, is required for the development of marginal zone and peritoneal B-1 B cells and additionally required for extrafollicular antibody responses to T-independent and -dependent immunogens.I?BNS has been identified as a member of the I?B family of NF-?B inhibitors, which undergoes induction upon TCR signaling. I?BNS mediates both positive and negative gene regulation, depending on individual cell type and/or cytokine.
Research Areas: Epigenetics and Nuclear Signaling, Immunology, Signal transduction
Recommended Dilutions: WB 1:500-1:2000, IHC 1:25-1:100
Size: 200 uL
Gene Accession: BC006273
Immunogen: Recombinant protein of human NFKBID
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Calculated MW: 33kDa
Tissue Specificity/Positive Control:
Cellular Localization: Nucleus.
Storage: Store at -20C. Avoid freeze / thaw cycles.