Caldesmo Polyclonal Antibody

Supplier: Elabscience
Product Type: Antibody
Clonality: Polyclonal
Descritpion: This gene encodes a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to Ca(2+)-calmodulin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca(2+)-dependent inhibition of smooth muscle contraction. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. 
Research Areas: Cancer, Cardiovascular, Signal transduction
Applications: IHC,ELISA
Recommended Dilutions: IHC 1:50-1:150
Size: 200 uL
Concentration: 0.5mg/mL
Swissprot: Q05682
Gene Accession: BC040354
Reactivity: Human,Rat
Host: Rabbit
Isotype: IgG
Immunogen: Recombinant protein of human Caldesmo
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Conjugation: Unconjugated
Calculated MW:
Tissue Specificity/Positive Control: High-molecular-weight caldesmon (isoform 1) is predominantly expressed in smooth muscles, whereas low-molecular-weight caldesmon (isoforms 2, 3, 4 and 5) are widely distributed in non-muscle tissues and cells. Not expressed in skeletal muscle or heart.
Cellular Localization: Cytoplasm
Storage: Store at -20C. Avoid freeze / thaw cycles.

Product Link: https://www.elabscience.com/p-caldesmon_polyclonal_antibody-30246.html
Manual Link: https://www.elabscience.com/viewpdf-30246-elabscience-E-AB-10191.PDF