Product Type: Antibody
Descritpion: Decapping is a key step in general and regulated mRNA decay. The protein encoded by this gene is a decapping enzyme. This protein and another decapping enzyme form a decapping complex, which interacts with the nonsense-mediated decay factor hUpf1 and may be recruited to mRNAs containing premature termination codons. This protein also participates in the TGF-beta signaling pathway. Alternative splicing of this gene results in multiple transcript variants.
Research Areas: Cancer, Epigenetics and Nuclear Signaling
Recommended Dilutions: IHC 1:100-1:300
Size: 200 uL
Gene Accession: BC007439
Immunogen: Recombinant protein of human DCP1A
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Tissue Specificity/Positive Control: Detected in heart, brain, placenta, lung, skeletal muscle, liver, kidney and pancreas.
Cellular Localization: Cytoplasm>P-body. Nucleus. Co-localizes with NANOS3 in the processing bodies (By similarity). Predominantly cytoplasmic, in processing bodies (PB). Nuclear, after TGFB1 treatment. Translocation to the nucleus depends on interaction with SMAD4.
Storage: Store at -20C. Avoid freeze / thaw cycles.