DDIT4L Polyclonal AntibodyE-AB-11149
Product Type: Antibody
Descritpion: REDD-2 (regulated in development and DNA damage response 2), also designated Rtp801L or DDIT4L (DNA-damage-inducible transcript 4-like), is a 193 amino acid cytoplasmic protein belonging to the DDIT4 family and is predominantly expressed in skeletal muscle. Considered a stress-inducted protein, REDD-2 is a negative regulator of the mTOR (mammalian target of rapamycin) pathway. mTOR is a serine/threonine kinase that plays an essential role in cell growth control and is an important regulator of skeletal muscle size. Highly expressed in human atherosclerotic lesions and macrophages, REDD-2 mediates monocyte cell death through reduction of Trx (thioredoxin-1) expression. REDD2 expression in macrophages increases oxidized LDL (oxLDL)-induced cell death, suggesting that REDD2 may play a critical role in arterial pathology.
Research Areas: Cell Biology
Recommended Dilutions: IHC 1:25-1:100
Size: 200 uL
Gene Accession: BC013592
Immunogen: Recombinant protein of human DDIT4L
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Tissue Specificity/Positive Control: Up-regulated in atherosclerotic plaques relative to healthy segments of the same artery.
Cellular Localization: Cytoplasmic
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-ddit4l_polyclonal_antibody-31190.html
Manual Link: https://www.elabscience.com/viewpdf-31190-elabscience-E-AB-11149.PDF