ZIC2 Polyclonal AntibodyE-AB-12210
Product Type: Antibody
Descritpion: This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. This protein functions as a transcriptional repressor and may regulate tissue specific expression of dopamine receptor D1. Mutations in this gene cause holoprosencephaly type 5. Holoprosencephaly is the most common structural anomaly of the human brain. A polyhistidine tract polymorphism in this gene may be associated with increased risk of neural tube defects. This gene is closely linked to a gene encoding zinc finger protein of the cerebellum 5, a related family member on chromosome 13.
Research Areas: Epigenetics and Nuclear Signaling, Neuroscience, Signal transduction
Recommended Dilutions: IHC 1:50-200
Size: 200 uL
Gene Accession: NP_009060
Immunogen: Synthetic peptide of human ZIC2
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Tissue Specificity/Positive Control:
Cellular Localization: Nucleus. Cytoplasm. Localizes in the cytoplasm in presence of MDFIC overexpression. Both phosphorylated and unphosphorylated forms are localized in the nucleus.
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-zic2_polyclonal_antibody-40050.html
Manual Link: https://www.elabscience.com/viewpdf-40050-elabscience-E-AB-12210.PDF