Product Type: Antibody
Descritpion: The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex.
Research Areas: Cancer, Cardiovascular, Metabolism, Signal transduction
Recommended Dilutions: IHC 1:10-1:50
Size: 200 uL
Gene Accession: NP_006244
Immunogen: Synthetic peptide of human PRKAB1
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Tissue Specificity/Positive Control:
Cellular Localization: Cytosol,Nucleus,nucleoplasm,Other locations:nucleotide-activated protein kinase complex
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-ampk_beta1_polyclonal_antibody-31698.html
Manual Link: https://www.elabscience.com/viewpdf-31698-elabscience-E-AB-12241.PDF