Product Type: Antibody
Descritpion: This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19.
Research Areas: Epigenetics and Nuclear Signaling
Recommended Dilutions: WB 1:200-1:1000, IHC 1:10-1:50
Size: 200 uL
Gene Accession: NP_001939
Immunogen: Synthetic peptide of human DUT
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Calculated MW: 27kDa
Tissue Specificity/Positive Control: Found in a variety of tissues.
Cellular Localization: Mitochondrion and Nucleus.
Storage: Store at -20C. Avoid freeze / thaw cycles.