GNRHR Polyclonal AntibodyE-AB-12492
Product Type: Antibody
Descritpion: This gene encodes the receptor for type 1 gonadotropin-releasing hormone. This receptor is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate. Following binding of gonadotropin-releasing hormone, the receptor associates with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Activation of the receptor ultimately causes the release of gonadotropic luteinizing hormone (LH) and follicle stimulating hormone (FSH). Defects in this gene are a cause of hypogonadotropic hypogonadism (HH). Alternative splicing results in multiple transcript variants encoding different isoforms. More than 18 transcription initiation sites in the 5' region and multiple polyA signals in the 3' region have been identified for this gene.
Research Areas: Cancer, Neuroscience
Recommended Dilutions: WB 1:500-1:2000
Size: 200 uL
Gene Accession: NP_000397
Immunogen: Synthetic peptide of human GNRHR
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Calculated MW: 28kDa
Tissue Specificity/Positive Control: Pituitary, ovary, testis, breast and prostate but not in liver and spleen.
Cellular Localization: Plasma Membrane,integral component of Plasma Membrane,Other locations:membrane
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-gnrhr_polyclonal_antibody-31942.html
Manual Link: https://www.elabscience.com/viewpdf-31942-elabscience-E-AB-12492.PDF