KCNH2 Polyclonal AntibodyE-AB-12497
Product Type: Antibody
Descritpion: This gene encodes a voltage-activated potassium channel belonging to the eag family. It shares sequence similarity with the Drosophila ether-a-go-go (eag) gene. Mutations in this gene can cause long QT syndrome type 2 (LQT2). Transcript variants encoding distinct isoforms have been identified. Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr). Isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1.
Research Areas: Cancer, Cardiovascular, Neuroscience
Recommended Dilutions: WB 1:500-1:2000
Size: 200 uL
Gene Accession: NP_000229
Immunogen: Synthetic peptide of human KCNH2
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Calculated MW: 90kDa
Tissue Specificity/Positive Control: Highly expressed in heart and brain.
Cellular Localization: Membrane.
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-kcnh2_polyclonal_antibody-31946.html
Manual Link: https://www.elabscience.com/viewpdf-31946-elabscience-E-AB-12497.PDF