HDAC3 Polyclonal AntibodyE-AB-12502
Product Type: Antibody
Descritpion: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene.
Research Areas: Cancer, Cardiovascular, Epigenetics and Nuclear Signaling, Metabolism, Stem cells
Recommended Dilutions: WB 1:200-1:1000
Size: 200 uL
Gene Accession: NP_003874
Immunogen: Synthetic peptide of human HDAC3
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Calculated MW: 49kDa
Tissue Specificity/Positive Control: Widely expressed.
Cellular Localization: Nucleus.
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-hdac3_polyclonal_antibody-31951.html
Manual Link: https://www.elabscience.com/viewpdf-31951-elabscience-E-AB-12502.PDF