Product Type: Antibody
Descritpion: This gene encodes a member of the syntaxin superfamily. Syntaxins are nervous system-specific proteins implicated in the docking of synaptic vesicles with the presynaptic plasma membrane. Syntaxins possess a single C-terminal transmembrane domain, a SNARE [Soluble NSF (N-ethylmaleimide-sensitive fusion protein)-Attachment protein REceptor] domain (known as H3), and an N-terminal regulatory domain (Habc). Syntaxins bind synaptotagmin in a calcium-dependent fashion and interact with voltage dependent calcium and potassium channels via the C-terminal H3 domain. This gene product is a key molecule in ion channel regulation and synaptic exocytosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Research Areas: Cancer, Metabolism, Neuroscience, Signal transduction
Recommended Dilutions: WB 1:500-1:2000, IHC 1:15-1:50
Size: 200 uL
Gene Accession: NP_004594
Immunogen: Synthetic peptide of human STX1A
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Calculated MW: 33kDa
Tissue Specificity/Positive Control: Isoform 1 is highly expressed in embryonic spinal chord and ganglia and in adult cerebellum and cerebral cortex. Isoform 2 is expressed in heart, liver, fat, skeletal muscle, kidney and brain.
Cellular Localization: Secreted and Cytoplasmic vesicle>secretory vesicle>synaptic vesicle membrane. Cell junction>synapse>synaptosome.
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-stx1a_polyclonal_antibody-32336.html
Manual Link: https://www.elabscience.com/viewpdf-32336-elabscience-E-AB-12894.PDF