API5 Polyclonal AntibodyE-AB-12981
Product Type: Antibody
Descritpion: This gene encodes an apoptosis inhibitory protein whose expression prevents apoptosis after growth factor deprivation. This protein suppresses the transcription factor E2F1-induced apoptosis and also interacts with, and negatively regulates Acinus, a nuclear factor involved in apoptotic DNA fragmentation. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
Research Areas: Cancer, Cell Biology
Recommended Dilutions: WB 1:200-1:1000
Size: 200 uL
Gene Accession: NP_001136402
Immunogen: Synthetic peptide of human API5
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Calculated MW: 59kDa
Tissue Specificity/Positive Control: Expressed in all tissues tested, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Highest levels in heart, pancreas and placenta. Highly expressed in several cancers. Preferentially expressed in squamous cell carcinoma versus adenocarcinoma in non-small cell lung cancer.
Cellular Localization: Cytoplasm and Nucleus. Cytoplasm. Mainly nuclear. Can also be cytoplasmic.
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-api5_polyclonal_antibody-32423.html
Manual Link: https://www.elabscience.com/viewpdf-32423-elabscience-E-AB-12981.PDF