CHRNA2 Polyclonal AntibodyE-AB-13149
Product Type: Antibody
Descritpion: Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels formed by a pentameric arrangement of alpha and beta subunits to create distinct muscle and neuronal receptors. Neuronal receptors are found throughout the peripheral and central nervous system where they are involved in fast synaptic transmission. This gene encodes an alpha subunit that is widely expressed in the brain. The proposed structure for nAChR subunits is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. Mutations in this gene cause autosomal dominant nocturnal frontal lobe epilepsy type 4. Single nucleotide polymorphisms (SNPs) in this gene have been associated with nicotine dependence.
Research Areas: Neuroscience
Recommended Dilutions: IHC 1:25-1:100
Size: 200 uL
Gene Accession: NP_000733
Immunogen: Synthetic peptide of human CHRNA2
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Tissue Specificity/Positive Control:
Cellular Localization: Cell junction>synapse>postsynaptic cell membrane. Cell membrane.
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-chrna2_polyclonal_antibody-32589.html
Manual Link: https://www.elabscience.com/viewpdf-32589-elabscience-E-AB-13149.PDF