LE/AF Purified Anti-Mouse CD357 Monoclonal Antibody

Supplier: Elabscience
Product Type: monoclonal antibody for FC
Description: GITR, Glucocorticoid-induced TNFR-related gene, is a member of the TNF receptor superfamily, also known as TNFRSF18, and AITR (in humans). It is expressed at low levels on resting T lymphocytes and at high levels on CD4+CD25+ T regulatory (Treg) cells. The expression of GITR on T cells can be upregulated upon activation. Interaction of GITR with its ligand (GITRL) has been demonstrated to augment T cell activation, proliferation, cytokine production, as well as MAPKs and NF-?B activation, and abrogate the inhibitory functions of CD4+CD25+ Treg cells. In vivo activation GITR causes development of autoimmune diseases and restores the suppressed immune responses.
Resarch Areas: Cancer, Immunology, Signal Transduction
Size: 500 ug
Clonality: Monoclonal
Clone No: DTA-1
Swissprot: O35714
Applications: FCM,IP
Recommended Usage:
Reactivity: Mouse
Host: Rat
Isotype: Rat IgG2b
Formulation: PBS, PH7.2
Purification: Protein G
Conjugation: Low endotoxin/Azide Free
Storage: Keep as concentrated solution. Store at 4°C as an undiluted liquid. For extended storage aliquot contents and freeze at -20°C or lower. Avoid freeze/thaw cycles.

Product Link: https://www.elabscience.com/p-le_af_purified_anti_mouse_cd357_monoclonal_antibody-39229.html
Manual Link: https://www.elabscience.com/viewpdf-39229-elabscience-E-AB-1351.PDF