Product Type: Antibody
Descritpion: CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. Alternative splicing results in multiple transcript variants encoding different isoforms.
Research Areas: Cancer, Epigenetics and Nuclear Signaling
Recommended Dilutions: IHC 1:50-1:200
Size: 200 uL
Gene Accession: BC043617
Immunogen: Recombinant protein of human DNMT3A
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Tissue Specificity/Positive Control: Highly expressed in fetal tissues, skeletal muscle, heart, peripheral blood mononuclear cells, kidney, and at lower levels in placenta, brain, liver, colon, spleen, small intestine and lung.
Cellular Localization: Nucleus. Cytoplasm. Accumulates in the major satellite repeats at pericentric heterochromatin.
Storage: Store at -20C. Avoid freeze / thaw cycles.