PITX2 Polyclonal AntibodyE-AB-14672
Product Type: Antibody
Descritpion: This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. The encoded protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression. This protein plays a role in the terminal differentiation of somatotroph and lactotroph cell phenotypes, is involved in the development of the eye, tooth and abdominal organs, and acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. Mutations in this gene are associated with Axenfeld-Rieger syndrome, iridogoniodysgenesis syndrome, and sporadic cases of Peters anomaly. A similar protein in other vertebrates is involved in the determination of left-right asymmetry during development. Alternatively spliced transcript variants encoding distinct isoforms have been described.
Research Areas: Cancer, Cardiovascular, Epigenetics and Nuclear Signaling, Developmental biology
Recommended Dilutions: WB 1:500-1:2000
Size: 200 uL
Gene Accession: BC013998
Immunogen: Recombinant protein of human PITX2
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Calculated MW: 35kDa
Tissue Specificity/Positive Control:
Cellular Localization: Nucleus,nucleoplasm,nucleus,Other locations:cytoplasm,transcription factor complex
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-pitx2_polyclonal_antibody-34100.html
Manual Link: https://www.elabscience.com/viewpdf-34100-elabscience-E-AB-14672.PDF