ACTN2 Polyclonal Antibody

Supplier: Elabscience
Product Type: Antibody
Clonality: Polyclonal
Descritpion: Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein witHuman, Mouseultiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smootHuman, Mouseuscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments.
Research Areas: Cancer, Cardiovascular, Signal transduction
Applications: WB,IHC,ELISA
Recommended Dilutions: WB 1:1000-1:5000, IHC 1:25-1:100
Size: 200 uL
Concentration: 0.4mg/mL
Swissprot: P35609
Gene Accession: NP_001094
Reactivity: Human,Mouse
Host: Rabbit
Isotype: IgG
Immunogen: Synthetic peptide of human ACTN2
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Conjugation: Unconjugated
Calculated MW: 104kDa
Tissue Specificity/Positive Control: Expressed in both skeletal and cardiac muscle.
Cellular Localization: Cytoplasm>myofibril>sarcomere>Z line. Colocalizes with MYOZ1 and FLNC at the Z-lines of skeletal muscle.
Storage: Store at -20C. Avoid freeze / thaw cycles.

Product Link: https://www.elabscience.com/p-actn2_polyclonal_antibody-36180.html
Manual Link: https://www.elabscience.com/viewpdf-36180-elabscience-E-AB-16785.PDF