Product Type: Antibody
Descritpion: Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein witHuman, Mouseultiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smootHuman, Mouseuscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments.
Research Areas: Cancer, Cardiovascular, Signal transduction
Recommended Dilutions: WB 1:1000-1:5000, IHC 1:25-1:100
Size: 200 uL
Gene Accession: NP_001094
Immunogen: Synthetic peptide of human ACTN2
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Calculated MW: 104kDa
Tissue Specificity/Positive Control: Expressed in both skeletal and cardiac muscle.
Cellular Localization: Cytoplasm>myofibril>sarcomere>Z line. Colocalizes with MYOZ1 and FLNC at the Z-lines of skeletal muscle.
Storage: Store at -20C. Avoid freeze / thaw cycles.