SMN1 Polyclonal AntibodyE-AB-16861
Product Type: Antibody
Descritpion: This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. The repetitiveness and complexity of the sequence have also caused difficulty in determining the organization of this genomic region. The telomeric and centromeric copies of this gene are nearly identical and encode the same protein.
Research Areas: Cancer, Epigenetics and Nuclear Signaling, Neuroscience
Recommended Dilutions: WB 1:200-1:1000
Size: 200 uL
Gene Accession: NP_000335
Immunogen: Synthetic peptide of human SMN1
Formulation: PBS with 0.05% sodium azide, 50% glycerol, PH7.3
Purification: Affinity purification
Calculated MW: 32kDa
Tissue Specificity/Positive Control: Expressed in a wide variety of tissues. Expressed at high levels in brain, kidney and liver, moderate levels in skeletal and cardiac muscle, and low levels in fibroblasts and lymphocytes. Also seen at high levels in spinal cord. Present in osteoclasts and mononuclear cells (at protein level).
Cellular Localization: Cytoplasm. Nucleus>gem. Localized in subnuclear structures next to coiled bodies, called Gemini of Cajal bodies.
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-smn1_polyclonal_antibody-36256.html
Manual Link: https://www.elabscience.com/viewpdf-36256-elabscience-E-AB-16861.PDF