Phospho-NF?B-p105/p50 (Ser337) Polyclonal AntibodyE-AB-20936
Product Category: Phospho/Acetyl/Methyl
Description: NFkB is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. Activated NFkB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFkB has been associated with a number of inflammatory diseases while persistent inhibition of NFkB leads to inappropriate immune cell development or delayed cell growth. NFKB1 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p105 and generation of p50 by a cotranslational processing. This antibody can bind both p105 and p50 isoforms of NFKB1.
Research Areas: Cancer, Cell Biology, Epigenetics and Nuclear Signaling, Immunology, Signal transduction
Size: 200 uL
Recommended Dilutions: WB 1:500-1:2000, IHC 1:100-1:300, IF 1:200-1:1000, ELISA 1:20000
Gene ID: 4790
Immunogen: Synthesized peptide derived from human NF?B-p105/p50 around the phosphorylation site of Ser337
Formulation: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Purification: Affinity purification
Storage: Store at -20C. Avoid freeze / thaw cycles.
Cellular Localization: Nucleus. Cytoplasm. Nuclear, but also found in the cytoplasm in an inactive form complexed to an inhibitor.
Product Link: https://www.elabscience.com/p-phospho_nf?b_p105_p50_(ser337)_polyclonal_antibody-25525.html
Manaul Link: https://www.elabscience.com/viewpdf-25525-elabscience-E-AB-20936.PDF