Phospho-Tuberin (Ser939) Polyclonal AntibodyE-AB-21182
Product Category: Phospho/Acetyl/Methyl
Description: In complex with TSC1, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling. Stimulates weakly the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 in vitro. Mutations in TSC2 lead to constitutive activation of RAP1A in tumors.
Research Areas: Cancer, Cell Biology, Epigenetics and Nuclear Signaling, Metabolism, Signal transduction
Size: 200 uL
Recommended Dilutions: WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:10000
Gene ID: 7249
Immunogen: Synthesized peptide derived from human Tuberin around the phosphorylation site of S939.
Formulation: PBS with 0.02% sodium azide,0.5% BSA and 50% glycerol pH 7.4.
Purification: Affinity purification
Observed MW: 200kDa
Storage: Store at -20C. Avoid freeze / thaw cycles.
Cellular Localization: Cytoplasm. Membrane. At steady state found in association with membranes.
Product Link: https://www.elabscience.com/p-phospho_tuberin_(ser939)_polyclonal_antibody-25771.html
Manaul Link: https://www.elabscience.com/viewpdf-25771-elabscience-E-AB-21182.PDF