Product Category: Phospho/Acetyl/Methyl
Description: Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues.
Research Areas: Cancer, Metabolism, Immunology, Signal transduction
Size: 200 uL
Recommended Dilutions: WB 1:500-1:2000, IHC 1:100-1:300, IF 1:50-1:200, ELISA 1:10000
Gene ID: 5295
Immunogen: Synthesized peptide derived from human PI 3-kinase p85? around the phosphorylation site of Tyr607
Formulation: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Purification: Affinity purification
Observed MW: 80kDa
Storage: Store at -20C. Avoid freeze / thaw cycles.
Cellular Localization: Cytosol,Endoplasmic reticulum,perinuclear endoplasmic reticulum membrane,Nucleus,Plasma Membrane,Other locations:cell-cell junction,cis-Golgi network,cytoplasm,membrane,phosphatidylinositol 3-kinase complex,phosphatidylinositol 3-kinase complex, class IA,protein complex