Phospho-DRP1 (Ser637) Polyclonal AntibodyE-AB-21251
Product Category: Phospho/Acetyl/Methyl
Description: Functions in mitochondrial and peroxisomal division. Mediates membrane fission through oligomerization into ring-like structures which wrap around the scission site to constict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism. Required for normal brain development. Facilitates developmentally-regulated apoptosis during neural tube development. Required for a normal rate of cytochrome c release and caspase activation during apoptosis. Also required for mitochondrial fission during mitosis. May be involved in vesicle transport.Isoform 1 and isoform 4 inhibit peroxisomal division when overexpressed.
Research Areas: Cancer, Cell Biology, Metabolism, Neuroscience, Signal transduction
Size: 200 uL
Recommended Dilutions: WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:10000
Gene ID: 10059
Immunogen: Synthesized peptide derived from human DRP1 around the phosphorylation site of Ser637
Formulation: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Purification: Affinity purification
Observed MW: 81kDa
Storage: Store at -20C. Avoid freeze / thaw cycles.
Cellular Localization: Cytoplasm>cytosol. Golgi apparatus. Endomembrane system. Mainly cytosolic. Translocated to the mitochondrial membrane through interaction with FIS1. Colocalized with MARCH5 at mitochondrial membrane. Localizes to mitochondria at sites of division. Associated with peroxisomal membranes, partly recruited there by PEX11B. May also be associated with endoplasmic reticulum tubules and cytoplasmic vesicles and found to be perinuclear. In some cell types, localizes to the Golgi complex.
Product Link: https://www.elabscience.com/p-phospho_drp1_(ser637)_polyclonal_antibody-25840.html
Manaul Link: https://www.elabscience.com/viewpdf-25840-elabscience-E-AB-21251.PDF