Phospho-JNK1/2/3 (Tyr185) Polyclonal Antibody

Supplier: Elabscience
Product Category: Phospho/Acetyl/Methyl
Description: c-Jun N-terminal kinases (JNKs) phosphorylate and augment transcriptional activity of c-Jun. JNKs originate from three genes that yield ten isoforms through alternative mRNA splicing, including JNK1?1,JNK1?1, JNK2?1, JNK2?1 and JNK3?1, which represent the p46 isoforms, and JNK1?2, JNK1?2, JNK2?2, JNK2?2 and JNK3?2, which represent the p54 isoforms. JNKs coordinate cell responses to stress and influence regulation of cell growth and ransformation. The human JNK1 (PRKM8, SAPK1, MAPK8) gene maps to chromosome 10q11.22 and shares 83% amino acid identity with JNK2. JNK1 is necessary for normal activation and differentiation of CD4 helper T (TH) cells into TH1 and TH2 effector cells. Capsaicin activates JNK1 and p38 in Ras-transformed human breast epithelial cells. Nitrogen oxides (NOx) upregulate JNK1 in addition to c-Fos, c-Jun and other signaling kinases, including MEKK1 and p38.
Research Areas: Cancer, Immunology, Signal transduction
Size: 200 uL
Concentration: 1mg/mL
Applications: WB,IHC-p,IF,ELISA
Recommended Dilutions: WB 1:500-1:2000, IHC 1:100-1:300, IF 1:50-1:200, ELISA 1:10000-1:20000
Clonality: Polyclonal
Clone No:
SwissProt: P45983,P45984,P53779
Gene ID: 5599/5601/5602
Reactivity: Human,Mouse,Rat
Host: Rabbit
Isotype: IgG
Immunogen: Synthesized peptide derived from human JNK1/2/3 around the phosphorylation site of Tyr185
Formulation: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Purification: Affinity purification
Conjugation: Unconjugated
Observed MW: 45kDa
Storage: Store at -20C. Avoid freeze / thaw cycles.
Cellular Localization: Cytoplasm. Nucleus.

Product Link: https://www.elabscience.com/p-phospho_jnk1_2_3_(tyr185)_polyclonal_antibody-25842.html
Manaul Link: https://www.elabscience.com/viewpdf-25842-elabscience-E-AB-21253.PDF