ERBB2 Monoclonal AntibodyE-AB-27570
Product Type: monoclonal antibody
Clone No: Clone:77
Description: HER2,also known as ErbB2 and Neu,is a 185-kDa transmembrane glycoprotein that is a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. It has no ligand binding domain of its own and therefore cannot bind growth factors. However,it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer,stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways,such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Amplification and/or overexpression of HER2 have been reported in numerous cancers,including
breast and ovarian tumors. HER2 is a therapeutic target for the treatment of breast cancer and other carcinomas.
Research Areas: Cancer, Immunology, Signal transduction, Tags & Cell Markers
Size: 200 uL
Gene ID: 2064
Recommended Dilutions: IHC 1:50-1:400
Immunogen: Fusion protein of HER2/ErbB2
Formulation: PBS with 0.02% sodium azide, 50% glycerol, PH7.3
Purification: Protein A purification
Calculated MW: 1255aa, 138kDa
Storage: Store at -20C. Avoid freeze / thaw cycles.
Tissue Specificity/Positive Control: Expressed in a variety of tumor tissues including primary breast tumors and tumors from small bowel, esophagus, kidney and mouth.
Cellular Localization: Cytoplasm. Nucleus and Cell membrane. Cytoplasm, perinuclear region. Nucleus. Translocation to the nucleus requires endocytosis, probably endosomal sorting and is mediated by importin beta-1/KPNB1.
Product Link: https://www.elabscience.com/p-erbb2_monoclonal_antibody-25317.html
Manual Link: https://www.elabscience.com/viewpdf-25317-elabscience-E-AB-27570.PDF