ARNTL Polyclonal AntibodyE-AB-30170
Product Type: Antibody
Descritpion: BMAL1, a basic helix–loop–helices with Per–Arnt–Sim (PAS) domain transcription factor, is one of components that has core clock function in mammals. It form a heterodimer with CLOCK, and induce the transcription of target genes by binding to E-box elements within their promoter regions. And this transcription is inhibited in a feedback loop by PER, and also by CRY proteins.Also BMAL1 is a key player in the regulation of metabolism, playing a role in adipogenesis and in the control of glucose and triglycerides levels.
Research Areas: Cancer, Cardiovascular, Epigenetics and Nuclear Signaling, Metabolism, Neuroscience
Recommended Dilutions: WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:10000-1:20000
Size: 200 uL
Immunogen: Synthesized peptide derived from human BMAL1 around the non-acetylation site of K538.
Formulation: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Purification: Affinity purification
Calculated MW: 69kDa
Tissue Specificity/Positive Control: Hair follicles (at protein level). Highly expressed in the adult brain, skeletal muscle and heart.
Cellular Localization: Nucleus. Cytoplasm. Nucleus, PML body. Shuttles between the nucleus and the cytoplasm and this nucleocytoplasmic shuttling is essential for the nuclear accumulation of CLOCK, target gene transcription and the degradation of the CLOCK-ARNTL/BMAL1 heterodimer. The sumoylated form localizes in the PML body. Sequestered to the cytoplasm in the presence of ID2.
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-arntl_polyclonal_antibody-26495.html
Manual Link: https://www.elabscience.com/viewpdf-26495-elabscience-E-AB-30170.PDF