Product Type: Antibody
Descritpion: This gene belongs to the beta-2 integrin family of membrane glycoproteins, which are are composed of non-covalently linked alpha and beta subunits to form a heterodimer. It encodes the alpha subunit of the cell surface heterodimers and is involved in the activation and adhesion functions of leukocytes. The gene is located about 11kb downstream of the integrin subunit alpha X gene, another member of the integrin family. It is expressed in the tissue and circulating myeloid leukocytes. Alternative splicing results in multiple transcript variants. ITGAD (Integrin Subunit Alpha D) is a Protein Coding gene. Diseases associated with ITGAD include Chronic Monocytic Leukemia and Alzheimer's Disease 14. Among its related pathways are GPCR Pathway and MAPK-Erk Pathway. An important paralog of this gene is ITGAX.
Research Areas: Immunology, Signal transduction
Recommended Dilutions: WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:10000-1:20000
Size: 200 uL
Immunogen: Synthesized peptide derived from the Internal region of human Integrin ?D.
Formulation: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Purification: Affinity purification
Calculated MW: 127kDa
Tissue Specificity/Positive Control: Expressed moderately on myelomonocytic cell lines and subsets of peripheral blood leukocytes and strongly on tissue-specialized cells, including macrophages foam cells within atherosclerotic plaques, and on splenic red pulp macrophages.
Cellular Localization: Plasma membrane
Storage: Store at -20C. Avoid freeze / thaw cycles.