PDE10A Polyclonal AntibodyE-AB-32525
Product Type: Antibody
Descritpion: The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase family. It plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This protein can hydrolyze both cAMP and cGMP to the corresponding nucleoside 5' monophosphate, but has higher affinity for cAMP, and is more efficient with cAMP as substrate. Alternatively spliced transcript variants have been described for this gene.PDE10A (Phosphodiesterase 10A) is a Protein Coding gene. Diseases associated with PDE10A include Dyskinesia, Limb And Orofacial, Infantile-Onset and Striatal Degeneration, Autosomal Dominant 2. Among its related pathways are GABAergic synapse and Signaling by GPCR. GO annotations related to this gene include 3,5-cyclic-nucleotide phosphodiesterase activity and cGMP binding. An important paralog of this gene is PDE11A.
Research Areas: Signal transduction
Recommended Dilutions: WB 1:500-1:2000, ELISA 1:5000
Size: 200 uL
Immunogen: Synthesized peptide derived from the N-terminal region of human PDE10A
Formulation: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Purification: Affinity purification
Calculated MW: 88kDa
Tissue Specificity/Positive Control: Abundant in the putamen and caudate nucleus regions of brain and testis, moderately expressed in the thyroid gland, pituitary gland, thalamus and cerebellum.
Cellular Localization: Cytoplasm. Located mostly to soluble cellular fractions.
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-pde10a_polyclonal_antibody-28850.html
Manual Link: https://www.elabscience.com/viewpdf-28850-elabscience-E-AB-32525.PDF