Product Type: Antibody
Descritpion: RRAGA (Ras Related GTP Binding A) is a Protein Coding gene. Diseases associated with RRAGA include Nut Allergy. Among its related pathways are RET signaling and mTOR signalling. GO annotations related to this gene include protein homodimerization activity and GTP binding. An important paralog of this gene is RRAGB.
Ras-homologous GTPases constitute a large family of signal transducers that alternate between an activated, GTP-binding state and an inactivated, GDP-binding state. These proteins represent cellular switches that are operated by GTP-exchange factors and factors that stimulate their intrinsic GTPase activity. All GTPases of the Ras superfamily have in common the presence of six conserved motifs involved in GTP/GDP binding, three of which are phosphate-/magnesium-binding sites (PM1-PM3) and three of which are guanine nucleotide-binding sites (G1-G3). Transcript variants encoding distinct isoforms have been identified. RRAGB (Ras Related GTP Binding B) is a Protein Coding gene. Diseases associated with RRAGB include Parasitic Helminthiasis Infectious Disease. Among its related pathways are RET signaling and PI3K / Akt Signaling. GO annotations related to this gene include GTP binding and guanyl ribonucleotide binding. An important paralog of this gene is RRAGA.
Research Areas: Cancer, Cell Biology, Metabolism, Microbiology, Signal transduction
Recommended Dilutions: WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:20000
Size: 200 uL
Immunogen: Synthesized peptide derived from the C-terminal region of human Rag A/B
Formulation: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Purification: Affinity purification
Calculated MW: 36-43kDa
Tissue Specificity/Positive Control: Ubiquitously expressed with highest levels of expression in skeletal muscle, heart, and brain.
Cellular Localization: Cytosol,Endosome,EGO complex,Lysosome,lysosomal membrane,lysosome,Nucleus,Other locations:cytoplasm,Gtr1-Gtr2 GTPase complex
Storage: Store at -20C. Avoid freeze / thaw cycles.