RPS6 Polyclonal AntibodyE-AB-32812
Product Type: Antibody
Descritpion: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 40S subunit. The protein belongs to the S6E family of ribosomal proteins. It is the major substrate of protein kinases in the ribosome, with subsets of five C-terminal serine residues phosphorylated by different protein kinases. Phosphorylation is induced by a wide range of stimuli, including growth factors, tumor-promoting agents, and mitogens. Dephosphorylation occurs at growth arrest. The protein may contribute to the control of cell growth and proliferation through the selective translation of particular classes of mRNA. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.
Research Areas: Cancer, Epigenetics and Nuclear Signaling
Recommended Dilutions: WB 1:500-1:2000, IF 1:100-1:300, ELISA 1:20000
Size: 200 uL
Immunogen: Synthesized peptide derived from human Ribosomal Protein Ser6 around the non-phosphorylation site of Ser235.
Formulation: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Purification: Affinity purification
Calculated MW: 29kDa
Tissue Specificity/Positive Control:
Cellular Localization: Cytosolic small ribosomal subunit,Nucleus,nucleolus,nucleoplasm,nucleus,Other locations:cell body,cytoplasmic ribonucleoprotein granule,dendrite,intracellular ribonucleoprotein complex,membrane,perinuclear region of cytoplasm,polysome,small ribosomal subunit
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-rps6_polyclonal_antibody-29137.html
Manual Link: https://www.elabscience.com/viewpdf-29137-elabscience-E-AB-32812.PDF