Product Type: Antibody
Descritpion: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. It is involved in macrophage cholesterol and phospholipids transport, and may regulate cellular lipid homeostasis in other cell types. Six alternative splice variants have been identified.
Research Areas: Cancer, Cardiovascular, Metabolism, Neuroscience, Signal transduction
Recommended Dilutions: WB 1:500-1:2000, IHC 1:100-300, ELISA 1:10000
Size: 200 uL
Immunogen: Synthesized peptide derived from the C-terminal region of human ABCG1
Formulation: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Purification: Affinity purification
Calculated MW: 76kDa
Tissue Specificity/Positive Control: Expressed in several tissues. Expressed in macrophages; expression is increased in macrophages from patients with Tangier disease.
Cellular Localization: Endoplasmic reticulum membrane. Golgi apparatus membrane. Predominantly localized in the intracellular compartments mainly associated with the endoplasmic reticulum (ER) and Golgi membranes.
Storage: Store at -20C. Avoid freeze / thaw cycles.