Claudin 17 Polyclonal AntibodyE-AB-33406
Product Type: Antibody
Descritpion: This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is intronless and is clustered with CLDN8 on chromosome 21q22.11.CLDN17 (Claudin 17) is a Protein Coding gene. Among its related pathways are Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling Pathways and Sertoli-Sertoli Cell Junction Dynamics. GO annotations related to this gene include identical protein binding and structural molecule activity. An important paralog of this gene is CLDN8.
Research Areas: Cancer, Signal transduction
Recommended Dilutions: WB 1:500-1:2000, ELISA 1:20000
Size: 200 uL
Immunogen: Synthesized peptide derived from the C-terminal region of human Claudin-17
Formulation: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Purification: Affinity purification
Calculated MW: 25kDa
Tissue Specificity/Positive Control: In the kidney, expressed in the proximal tubule and in the Henle's loop. In the distal convoluted tubule, not expressed in all tubules. Not detected in the collecting duct (at protein level).
Cellular Localization: Integral membrane protein.
Storage: Store at -20C. Avoid freeze / thaw cycles.
Product Link: https://www.elabscience.com/p-claudin_17_polyclonal_antibody-29731.html
Manual Link: https://www.elabscience.com/viewpdf-29731-elabscience-E-AB-33406.PDF