Product Type: Antibody
Descritpion: This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes within Golgi compartments, endosomes, and lysosomes, and is cleaved into a stable soluble form. The soluble form is required for the intracellular processing of some glycolipids into a form that can be presented by other CD1 family members. Many alternatively spliced transcript variants encoding different isoforms have been described. Additional transcript variants have been found; however, their biological validity has not been determined.CD1E (CD1e Molecule) is a Protein Coding gene. Diseases associated with CD1E include Mycobacterium Malmoense and Autoimmune Disease Of Central Nervous System. Among its related pathways are Tight junction and Hematopoietic cell lineage. GO annotations related to this gene include lipid binding and lipopeptide binding. An important paralog of this gene is CD1B.
Research Areas: Immunology
Recommended Dilutions: WB 1:500-1:2000, IHC 1:100-300, ELISA 1:20000
Size: 200 uL
Immunogen: Synthesized peptide derived from the C-terminal region of human CD1E.
Formulation: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Purification: Affinity purification
Calculated MW: 36kDa
Tissue Specificity/Positive Control: Expressed on cortical thymocytes, dendritic cells, Langerhans cells, on certain T-cell leukemias, and in various other tissues.
Cellular Localization: Lysosome lumen and Golgi apparatus membrane. Early endosome. Late endosome. Predominantly localized in the trans-Golgi network in immature dendritic cells, and as a cleaved, soluble protein in the lysosome lumen of mature dendritic cells.
Storage: Store at -20C. Avoid freeze / thaw cycles.