Product Type: Antibody
Descritpion: Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. May be involved in brain-to-blood efflux. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. When overexpressed, the transfected cells become resistant to mitoxantrone, daunorubicin and doxorubicin, display diminished intracellular accumulation of daunorubicin, and manifest an ATP-dependent increase in the efflux of rhodamine 123.
Research Areas: Cancer, Metabolism, Signal transduction, Stem cells, Tags & Cell Markers
Recommended Dilutions: WB 1:500-1:2000, IHC 1:100-1:300 ELISA 1:10000
Size: 200 uL
Immunogen: Synthesized peptide derived from the Internal region of human ABCG2.
Formulation: PBS with 0.02% sodium azide,0.5% BSA and 50% glycerol pH 7.4.
Purification: Affinity purification
Calculated MW: 72kDa
Tissue Specificity/Positive Control: Highly expressed in placenta. Low expression in small intestine, liver and colon.
Cellular Localization: Cell membrane.
Storage: Store at -20C. Avoid freeze / thaw cycles.