Product Type: Antibody
Descritpion: The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for this gene.SIRPA (Signal Regulatory Protein Alpha) is a Protein Coding gene. Diseases associated with SIRPA include Bladder Neck Obstruction and Autoimmune Hemolytic Anemia. Among its related pathways are Cell junction organization and Adhesion. GO annotations related to this gene include SH3 domain binding. An important paralog of this gene is SIRPB1.
Research Areas: Cancer, Cardiovascular, Neuroscience
Recommended Dilutions: WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:5000-1:10000
Size: 200 uL
Immunogen: Synthesized peptide derived from the Internal region of human SIRP-?1/?1.
Formulation: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Purification: Affinity purification
Calculated MW: 43-54kDa
Tissue Specificity/Positive Control: Ubiquitous. Highly expressed in brain. Detected on myeloid cells, but not T-cells. Detected at lower levels in heart, placenta, lung, testis, ovary, colon, liver, small intestine, prostate, spleen, kidney, skeletal muscle and pancreas.
Cellular Localization: Extracellular region or secreted,extracellular exosome,Plasma Membrane,Other locations:ficolin-1-rich granule membrane,integral component of membrane,membrane,tertiary granule membrane
Storage: Store at -20C. Avoid freeze / thaw cycles.