Phospho-ERK 1/2 (Tyr222/205) Monoclonal Antibody

Supplier: Elabscience
Product Category: Phospho/Acetyl/Methyl
Description: Involved in both the initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors such as ELK1. Phosphorylates EIF4EBP1; required for initiation of translation. Phosphorylates microtubule-associated protein 2 (MAP2). Phosphorylates SPZ1 (By similarity). Phosphorylates heat shock factor protein 4 (HSF4) and ARHGEF2.Acts as a transcriptional repressor. Binds to a [GC]AAA[GC] consensus sequence. Repress the expression of interferon gamma-induced genes. Seems to bind to the promoter of CCL5, DMP1, IFIH1, IFITM1, IRF7, IRF9, LAMP3, OAS1, OAS2, OAS3 and STAT1. Transcriptional activity is independent of kinase activity.
Research Areas: Cnacer,Signal Transduction,Neuroscience
Size: 200 uL
Concentration: 1mg/mL
Applications: IHC-p
Recommended Dilutions: IHC 1:100-200
Clonality: Monoclonal
Clone No: Clone:4D4
SwissProt: P27361,P28482
Gene ID: 5594/5595
Reactivity: Human,Mouse,Rat
Host: Mouse
Isotype: IgG
Immunogen: Synthetic Peptide of Phospho-ERK 1/2 (Tyr222/205)
Formulation: PBS with 0.02% sodium azide, 0.5% BSA and 50% glycerol, pH7.4
Purification: Protein A purification
Conjugation: Unconjugated
Observed MW:
Storage: Store at -20C. Avoid freeze / thaw cycles.
Cellular Localization: Nucleus.

Product Link: https://www.elabscience.com/p-phospho_erk_1_2_(tyr222_205)_monoclonal_antibody-41273.html
Manaul Link: https://www.elabscience.com/viewpdf-41273-elabscience-E-AB-51039.PDF