Recombinant Mouse Low Affinity Immunoglobulin Gamma Fc Region Receptor IV Protein

Supplier: Elabscience Product Name: Recombinant Mouse Low Affinity Immunoglobulin Gamma Fc Region Receptor IV Protein Catalog No. PKSM041244 Product Type: recombinant protein Size: 50 ug Activity: 1. Measured by its ability to bind human IgG1 (Fc) in a functional ELISA.2. Labeling ratio of biotin to protein: 0.6 Protein Construction: Recombinant Mouse Low Affinity Immunoglobulin Gamma Fc Region Receptor IV is produced by our Mammalian expression system and the target gene encoding Gly21-Gln203 is expressed with a 6His tag at the C-terminus. Sequence: Met 1-Gln 203 Fusion Tag: C-6His Accession: NP_653142.2 Species: Mouse Expressed Host: Human Cells Shipping Conditions: In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise. Purity: ?95% as determined by reducing SDS-PAGE. Endotoxin: <1.0 EU per ?g as determined by LAL test. Stability: Lyophilized protein should be stored at < -20?, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7? for 2-7 days.
Aliquots of reconstituted samples are stable at < -20? for 3 months Molecular Weight: 21.9 kDa Applied MM: 28-35kDa Formulation: Lyophilized from a 0.2 ?m filtered solution of PBS,pH7.4. Reconstitution: Please refer to it for detailed information. Background: Fcgr4, also known as CD16-2, is one of the receptors for Fc region of IgG which involve in immune responses. Fcgr4 mainly functions in cellular response to lipopolysaccharide, NK T cell proliferation, regulation of sensory perception of pain, wound healing etc. Three groups are included for Fc ? receptors (FcR), and they are Fc ? RI (CD64), Fc ? RII (CD32), and Fc ? RIII (CD16). Among these, CD64 possess high affinity even for monomeric IgG, while CD32 and CD16 display a relative lower affinity for IgG. Genes encodes these receptors are diverse differing by species and cell types. The aggregation of FcR having immunoreceptor tyrosine-based activation motifs (ITAMs) activates sequentially src family tyrosine kinases and syk family tyrosine kinases that connect transduced signals to common activation pathways shared with other receptors. FcR with ITAMs elicit cell activation, endocytosis, and phagocytosis. Fcgr4 belongs to Fc ? RIII (CD16) group.